SARI: New Anti-tumor Gene Identified

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Researchers from Virginia Commonwealth University identified SARI; a new anti-tumor gene. SARI suppresses a key protein that is over expressed in 90% of human cancers.

When investigators delivered SARI to cancer cells using a virus the infected cancer cells stopped dividing and died. This discovery has revealed a novel mode of interferon- induced (IFN-induced) anti-tumor growth suppression.

Since most cancers grow in a similar manner – SARI could be an effective anti-cancer treatment for many tumors and open the door to effective gene therapy for cancer.

Read about this research in The Proceedings of National Academy of Sciences. Zao-zhong Sua, Seok-Geun Leea, Luni Emdada, Irina V. Lebdevaa, Pankaj Guptaa, Kristoffer Valeriec, Devanand Sarkara, and Paul B. Fishera (2008) Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). PNAS 105(52): 20906-20911.

http://www.pnas.org/content/early/2008/12/12/0807975106.abstract